NON UK RESIDENTS can buy Tramadol 50mg here

Zydol Soluble Tablets are for Oral Administration dissolved in water.

Zydol SR (Slow Release) are prolonged release tablets.

Zydol XL (eXtended Release) are prolonged release tablets.

Opioid painkillers work by mimicking the action of naturally occurring pain-reducing chemicals called endorphins. Endorphins are found in the brain and spinal cord and reduce pain by combining with opioid receptors.

Zydol tramadol mimicks the action of natural endorphins by combining with the opioid receptors in the brain and spinal cord. This blocks the transmission of pain signals sent by the nerves to the brain.

Important information about Zydol

This medicine may cause drowsiness. If affected do not drive or operate machinery. Avoid drinking alcohol while taking Zydol. Some people may experience withdrawal symptoms when they stop taking Zydol. These may include anxiety or having difficulty sleeping. Tell your doctor if you experience withdrawal symptoms after stopping this medicine. Zydol is not recommended for children under 12 years of age. This medicine should not be used during pregnancy.

Use with caution in:

  • Elderly people
  • Decreased kidney function
  • Decreased liver function
  • Asthma
  • Slow, shallow breathing (respiratory depression)
  • History of drug dependence or abuse
  • Head injury
  • Increased pressure in the brain (raised intracranial pressure)
  • Reduced blood flow to vital internal organs (shock)
  • History of convulsions, eg epilepsy.

Not to be used in:

  • People under the influence of (intoxicated with) alcohol, sleeping tablets, tranquilizers, psychotropic drugs (those affecting mood or emotions) or other painkillers that act on the brain, eg morphine, codeine
  • People who have taken a monoamine-oxidase inhibitor antidepressant (MAOI) in the last 14 days
  • Pregnancy
  • Breastfeeding
  • Uncontrolled epilepsy


Zydol Side effects

These are some of the side effects associated with Zydol.

  • Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
  • Dizziness
  • Drowsiness
  • Headache
  • Sweating
  • Awareness of your heartbeat (palpitations)
  • Increased heart rate (tachycardia)
  • A drop in blood pressure that occurs when going from lying down to sitting or standing, which results in dizziness and lightheadedness (postural hypotension)
  • Skin reactions such as rash and itch
  • Blurred vision
  • Dry mouth
  • False perceptions of things that are not really there (hallucinations)
  • Nightmares
  • Confusion
  • Changes in mood
  • Slow, shallow breathing (respiratory depression)
  • Muscle weakness
  • Difficulty passing urine

The side effects listed above may not include all of the side effects reported by the drug’s manufacturer.

How can this medicine affect other medicines?

It is important to tell your doctor what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor before taking any new medicines while taking this one, to ensure that the combination is safe.

Zydol should not be taken at the same time as, or within two weeks of, MAOI antidepressants such as phenelzine or tranylcypromine.

There may be an increased risk of convulsions or seizures if tramadol is taken with the following medicines:

  • antipsychotic medicines
  • bupropion
  • mefloquine
  • SSRI antidepressants (eg fluoxetine)
  • tricyclic antidepressants (eg amitriptyline)

If Zydol is taken with SSRI antidepressants such as fluoxetine, or triptans for migraine such as sumatriptan, there may also be an increased risk of other side effects, as all these medicines enhance the activity of serotonin in the brain.

There may be an increased risk of drowsiness if Zydol is taken with any of the following:

  • alcohol
  • antipsychotics, eg haloperidol
  • barbiturates, eg phenobarbital, amobarbital
  • benzodiazepines, eg diazepam, temazepam
  • other opioids, eg morphine, codeine
  • sedating antihistamines, eg chlorphenamine, hydroxyzine
  • sleeping tablets, eg zopiclone
  • tricyclic antidepressants, eg amitriptyline

Carbamazepine may decrease the blood level of Zydol tramadol, which may make it less effective at relieving pain.

Zydol may enhance the anti-blood-clotting effect of anticoagulant medicines such as warfarin. If you are taking warfarin your blood clotting time (INR) should be monitored when you start and stop treatment with tramadol.